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  • from datetime import datetime, timedelta
    
    from typing import Tuple
    
    import numpy as np
    import pydicom
    
    
    """
    Since DICOM images only allow images stored in short integer format,
    the Siemens scanner software multiplies values by a factor before storing
    so that no precision is lost.
    The scale can be found in this private DICOM tag.
    """
    DCM_TAG_PIXEL_SCALE_FACTOR = 0x00331038
    """
    Maximum value that can be stored in an unsigned integer with 16 bist.
    """
    UINT16_MAX = 2**16 - 1
    
    """
    DICOM images always contain UIDs to indicate their uniqueness.
    Thus, when a DICOM image is updated, UIDs have to be changed for
    which the following prefix is used.
    """
    UID_PREFIX = "1.2.826.0.1.3680043.2.521."
    
    
    
    def load_dcm(filename: str) -> Tuple[pydicom.dataset.FileDataset, np.ndarray]:
        """
        Load a DICOM image, the data as a numpy array and apply normalization of the Siemens SPECT/CT
        Scanner.
    
        :param filename: filename of the DICOM image
        :return: the dicom header and the scaled image as a numpy array
        """
        dcm = pydicom.dcmread(filename)
        image = dcm.pixel_array / dcm[DCM_TAG_PIXEL_SCALE_FACTOR].value
        return dcm, image
    
    
    def load_dcm_img(filename: str) -> np.ndarray:
        """
        Load a DICOM image as a numpy array and apply normalization of the Siemens SPECT/CT
        Scanner.
    
        :param filename: filename of the DICOM image
        :return: the image scaled and loaded into a numpy array
        """
        _, image = load_dcm(filename)
        return image
    
    
    def scale_image(image: np.ndarray, initial_scale=10000000) -> Tuple[np.ndarray, float]:
        """
        For memory efficiency, the Siemens SPECT/CT does not store images as floating point
        numbers, but as unsigned integers with 16 bits. In order to somewhat keep precision,
        the floating points are scaled with a factor of 10^x where x is chosen so in a way
        that keeps the numbers in range of uint16. This function replicated this process.
    
        :param image: an image in floating points format
        :param initial_scale: the initial scale which is reduced until the maximum number
        is smaller than the maximum uint16 number
        :return: the image scaled and converted to uint16 as well as the used scaling factor
        """
        scale = initial_scale
        while (scale * image.max()) > UINT16_MAX:
            scale = scale / 10
        image = (image * scale).astype(np.uint16)
        return image, scale
    
    
    def update_dcm(
        dcm: pydicom.dataset.FileDataset, image: np.ndarray
    ) -> pydicom.dataset.FileDataset:
        """
        Update the image data in a DICOM file. This function scales the image, converts
        it to unsigned integers with 16 bits and updates the pixel data in the DICOM file.
        Additionally, other related tags in the DICOM header, such as image dimensions and
        maximum pixel values, are updated accordingly.
        Note that this function modifies the given DICOM file. If you want to keep the old
        one, you should copy it first.
    
        :param dcm: the DICOM file to be udpated
        :param image: the image put into the DICOM file
        :return: the updated DICOM file
        """
        image, scale = scale_image(image)
    
        dcm.NumberOfFrames = image.shape[0]
        dcm.NumberOfSlices = image.shape[0]
        dcm.SliceVector = list(range(1, image.shape[0] + 1))
        dcm.Columns = image.shape[1]
        dcm.Rows = image.shape[2]
        dcm.PixelData = image.tobytes()
        dcm.WindowWidth = image.max()
        dcm.WindowCenter = image.max() / 2
        dcm.LargestImagePixelValue = image.max()
        dcm[DCM_TAG_PIXEL_SCALE_FACTOR].value = scale
        return dcm
    
    def change_uid(dcm: pydicom.dataset.FileDataset) -> pydicom.dataset.FileDataset:
        """
        Change the UIDs (SeriesInstance and SOPInstance) in a DICOM header so that
        it becomes its own unique file. Note that this method does not guarantee
        that the UIDs are fully unique. Since the creation of UIDs is time dependent,
        this function should not be used to rapidly change many UIDs.
    
        :param dcm: the DICOM file to be udpated
        :return: the DICOM file with updated UIDs
        """
    
        now = datetime.now()
        soon = now + timedelta(seconds=1)
    
        dcm.SeriesInstanceUID = UID_PREFIX + now.strftime("%Y%m%d%H%M%S")
        dcm.SOPInstanceUID = UID_PREFIX + soon.strftime("%Y%m%d%H%M%S")
        return dcm